The mayor research field has been the study of inflammation,- damage and repair- mechanism at the molecular and cellular level in liver cells in animal models and in human material. Furthermore liver regeneration and liver tumor development have become of great importance at the research and at the clinical level in the last ten years. Of special importance is the study of the role of Inflammation in triggering tumor development in adult stem cells of the different gastrointestinal organs. The Pathophysiology of the acute phase reaction and of the iron metabolism within the liver has been a hot topic of the last 3 years.

Dr. Ramadori graduated in Bologna 1976, moved than to the Free University of Berlin (1977-1981) and than to the University of Mainz (1981-1992). From there he moved to the Harvard University (1984/1985) where he spend a research period at the laboratory of cell biology of the Children Hospital (Enders building). There he dedicated his attention to the regulation of protein synthesis in Hepatocytes at the molecular level (RNA and Protein level). He became Associate Professor of Internal Medicine in Mainz 1987 and Professor of Medicine and Chairman of Gastroenterology/Endocrinology and Infections Diseases at the University of Göttingen in October 1992. He has been President of the German Association for the study of liver for the year 2006/2007.

Christiansen H, Sheikh N, Saile B, Reuter F, Rave-Frank M, Hermann RM, Dudas J, Hille A, Hess CF, Ramadori G . x-Irradiation in rat liver: consequent upregulation of hepcidin and downregulation of hemojuvelin and ferroportin-1 gene expression. Radiology. 2007 Jan;242(1):189-97.
Dudas J, Elmaouhoub A, Mansuroglu T, Batusic D, Tron K, Saile B, Papoutsi M, Pieler T, Wilting J, Ramadori G. Prospero-related homeobox 1 (Prox1) is a stable hepatocyte marker during liver development, injury and regeneration, and is absent from "oval cells". Histochem Cell Biol. 2006 Nov;126(5):549-562.
Sheikh N, Tron K, Dudas J, Ramadori G. Cytokine-induced neutrophil chemoattractant-1 is released by the noninjured liver in a rat acute-phase model. Lab Invest. 2006 Aug;86(8):800-14.
Sheikh N, Batusic DS, Dudas J, Tron K, Neubauer K, Saile B, Ramadori G. Hepcidin and hemojuvelin gene expression in rat liver damage: in vivo and in vitro studies. Am J Physiol Gastrointest Liver Physiol. 2006 Sep;291(3):G482-90.
Tron K, Samoylenko A, Musikowski G, Kobe F, Immenschuh S, Schaper F, Ramadori G, Kietzmann T. Regulation of rat heme oxygenase-1 expression by interleukin-6 via the Jak/STAT pathway in hepatocytes. J Hepatol. 2006 Jul;45(1):72-80.
Baumhoer D, Lorf T, Gunawan B, Armbrust T, Fuzesi L, Ramadori G.Hepatic tumorigenesis in acute hepatic failure. Eur J Gastroenterol Hepatol. 2005 Oct;17(10):1125-30.
Batusic DS, Cimica V, Chen Y, Tron K, Hollemann T, Pieler T, Ramadori G. Identification of genes specific to "oval cells" in the rat 2-acetylaminofluorene/partial hepatectomy model. Histochem Cell Biol. 2005 Sep;124(3-4):245-60.
Cimica V, Batusic D, Chen Y, Hollemann T, Pieler T, Ramadori G. Transcriptome analysis of rat liver regeneration in a model of oval hepatic stem cells.Genomics. 2005 Sep;86(3):352-64.
Tron K, Novosyadlyy R, Dudas J, Samoylenko A, Kietzmann T, Ramadori G. Upregulation of heme oxygenase-1 gene by turpentine oil-induced localized inflammation: involvement of interleukin-6. Lab Invest. 2005 Mar;85(3):376-87.
Saile B, Eisenbach C, Dudas J, El-Armouche H, Ramadori G. Interferon-gamma acts proapoptotic on hepatic stellate cells (HSC) and abrogates the antiapoptotic effect of interferon-alpha by an HSP70-dependant pathway. Eur J Cell Biol. 2004 Sep;83(9):469-76.
Ramadori G, Saile B. Inflammation, damage repair, immune cells, and liver fibrosis: specific or nonspecific, this is the question. Gastroenterology. 2004 Sep;127(3):997-1000.
Saile B, Eisenbach C, El-Armouche H, Neubauer K, Ramadori G. Antiapoptotic effect of interferon-alpha on hepatic stellate cells (HSC): a novel pathway of IFN-alpha signal transduction via Janus kinase 2 (JAK2) and caspase-8. Eur J Cell Biol. 2003 Jan;82(1):31-41.